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MYOPIA
Animal Models to Clinical Trials


CONTENTS

FRONT MATTER
Roger W. Beuerman, Seang-Mei Saw, Donald T. H. Tan and Tien-Yin Wong
i
Section 1 Epidemiology and Risk Factors
Epidemiology of Myopia and Myopic Shift in Refraction
Barbara E. K. Klein
3
Environmental Risk Factors for Myopia in Children
Wilson C. J. Low, Tien-Yin Wong and Seang-Mei Saw
23
Gene-Environment Interactions in the Aetiology of Myopia
Ian G. Morgan and Kathryn A. Rose
45
The Economics of Myopia
Marcus C. C. Lim and Kevin D. Frick
63
Section 2 Clinical Studies and Pathologic Myopia
Quality of Life and Myopia
Ecosse L. Lamoureux and Hwee-Bee Wong
83
Ocular Morbidity of Pathological Myopia
V. Swetha E. Jeganathan, Seang-Mei Saw and Tien-Yin Wong
97
Myopia and Glaucoma
Shamira A. Perera and Tin Aung
121
The Myopic Retina
Shu-Yen Lee
137
Retinal Function
Chi D. Luu and Audrey W. L. Chia
149
Section 3 Genetics of Myopia
New Approaches in the Genetics of Myopia
Liang K. Goh, Ravikanth Metlapally and Terri Young
163
Twins Studies and Myopia
Maria Schäche and Paul N. Baird
183
TIGR, TGFB1, cMET, HGF, Collagen Genes, and Myopia
Chiea-Chuen Khor
201
Statistical Analysis of Genome-wide Association Studies for Myopia
Yi-Ju Li and Qiao Fan
215
Section 4 Animal Models and the Biological Basis of Myopia
The Relevance of Studies in Chicks for Understanding Myopia in Humans
Josh Wallman and Debora L. Nickla
239
The Mechanisms Regulating Scleral Change in Myopia
Neville A. McBrien
267
The Mouse Model of Myopia
Frank Schaeffel
303
Gene Analysis in Experimental Animal Models of Myopia
Roger W. Beuerman, Liang K. Goh and Veluchamy A. Barathi
331
Section 5 Interventions for Myopia
Atropine and Other Pharmacological Approaches to Prevent Myopia
Louis M. G. Tong, Veluchamy A. Barathi and Roger W. Beuerman
345
Physical Factors in Myopia and Potential Therapies
Wallace S. Foulds and Chi D. Luu
361
BACK MATTER
Roger W. Beuerman, Seang-Mei Saw, Donald T. H. Tan and Tien-Yin Wong
387
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