PROTEIN–PROTEIN COMPLEXES<br> Analysis, Modeling and Drug Design

PROTEIN–PROTEIN COMPLEXES
Analysis, Modeling and Drug Design

CONTENTS


FRONT MATTER Martin Zacharias	1
X-ray Study of Protein–Protein Complexes and Analysis of Interfaces Joel Janin	1
A Structural Perspective on Protein–Protein Interactions in Macromolecular Assemblies Ranjit P. Bahadur	25
Energetics of Protein–Protein Interactions Ilian Jelesarov	46
Kinetics of Biomacromolecular Complex Formation: Theory and Experiment Georgi V. Pachov, Razif R. Gabdoulline and Rebecca C. Wade	89
Evolutionary Trace of Protein Functional Determinants Olivier Lichtarge	119
Protein–Protein Docking Adrien Saladin and Chantal Prevost	147
Data-driven Docking: Using External Information to Spark the Biomolecular Rendez-vous Adrien S. J. Melquiond and Alexandre M. J. J. Bonvin	182
High-resolution Protein–Protein Docking Nir London and Ora Schueler-Furman	209
Scoring and Refinement of predicted Protein–Protein Complexes Martin Zacharias	236
Motif-Mediated Protein Interactions and their Role in Disease Holger Dinkel and Heinrich Sticht	272
Prediction and Calculation of Protein–Protein Binding Affinities and Mutation Effects Sébastien Fiorucci, Serge Antonczak and Jérôme Golebiowski	295
Small-Molecule Inhibitors of Protein–Protein Interactions Thorsten Berg	318
Protein Dynamics and Drug Design: The Role of Molecular Simulations Giulia Morra, Alessandro Genoni and Giorgio Colombo	340
BACK MATTER Martin Zacharias	387
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